Comparison of two different doses of propofol and its effect on hemodynamic response

A comparative study of haemodynamic responses of propofol induction between BIS guided dose and sleep dose

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/06/033990

Enrollment

Registered

2021-06-04

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Propofol: Comparison between sleep dose and BIS guided dose of propofol on haemodynamics. Sleep dose of propofol given by bolus intravenously till patient has loss of verbal command and

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1&2 Elective surgeries under general anaesthesia Patients with a signed informed written consent form

Exclusion criteria

Exclusion criteria: Patient refusal History of cardiac diseases like dilated cardiomyopathy,CCF, Arrhythmias etc History of uncontrolled hypertension and hypotension Patients with hepatic or renal dysfunction, pregnancy or any serious medical conditions that would interfere with cardiovascular response Patients with history of allergy to any GA drugs Cases lasting less than 30mins

Design outcomes

Primary

Measure	Time frame
To compare sleep guided dose of propofol with BIS guided dose on haemodynamic responseTimepoint: Baseline,15minutes intraoperative and 15minutes postoperatively	—

Secondary

Measure	Time frame
To Assess sedation scaleTimepoint: Postoperative Period upto 48 hrs	—

Countries

India

Contacts

Public ContactKeisham Upendra

Jawaharlal Nehru Institute of Medical sciences

drupendrakeisham@rediffmail.com9436039203

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026