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Effects of antibiotic gel in postoperative oral cancer surgery- A RCT

Efficacy of topical antibiotic gel administration in reducing oral bacterial growth and infective complications after oral cancer surgery - A RCT

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/06/033966
Enrollment
126
Registered
2021-06-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C069- Malignant neoplasm of mouth, unspecified

Interventions

Intervention1: METRONIDAZOLE AND CHLORHEXIDINE ORAL GEL: SIX HOURLY APPLICATION OF 1% METRONIDAZOLE AND 1% CHLORHEXIDINE ORAL GEL FOR FIRST 48 HRS AND 12 HRLY FOR NEXT 12 DAYS, AFTER ORAL CANCER SURGE

Sponsors

DR GNANAVEL N
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: HISTOLOGICALLY PROVEN SCC OF ORAL CAVITY REQUIRING CURATIVE SURGERY WHICH INCLUDES TUMOUR RESECTION, NECK DISSECTION, FLAP RECONSTRUCTION WITH OR WITHOUT TRACHEOSTOMY. PERFORMANCE STATUS 0 AND 1

Exclusion criteria

Exclusion criteria: RECURRENT TUMOURS POST RADIOTHERAPY NECROSIS OF RECONSTRUCTION FLAPS

Design outcomes

Primary

MeasureTime frame
1. EFFECT OF TOPICAL ANTIMICROBIAL GEL IN REDUCING QUALITATIVE AND QUANTITATIVE BACTERIAL LOAD IN THE SALIVA, AFTER ORAL CANCER SURGERY 2. EFFECT OF TOPICAL ANTIMICROBIAL GEL IN REDUCING THE SSI RATE IN SKIN FLAPS OR TRACHEOSTOMY SITE INFECTIONS AFTER ORAL CANCER SURGERYTimepoint: T-1 TO 30 DAYS—

Secondary

MeasureTime frame
PATTERN OF BACTERIAL FLORA BOTH AEROBIC AND ANAEROBIC IN THE PERIOPERATIVE PERIOD IN ORAL CANCER SURGERYTimepoint: T-1 TO 30 DAYS—

Countries

India

Contacts

Public ContactDR GNANAVEL N

ARMED FORCES MEDICAL COLLEGE PUNE

drandyaiyer@gmail.com7080317133

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026