Extended intensive care in cases of brain death due to traumatic brain injury having diffuse axonal injury

Proof of concept study to evaluate possibility of reversal in clinically diagnosed brain death subjects following road traffic accident having diffuse axonal injury by extending aggressive critical care for 15 days along with laser and electric stimulation

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/06/033958

Enrollment

Registered

2021-06-02

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: S062- Diffuse traumatic brain injury Health Condition 3: S062- Diffuse traumatic brain injury Health Condition 4: S062- Diffuse traumatic brain injury

Interventions

Intervention1: Extended intensive care: prolonged care with median nerve stimulation and low level laser therapy Control Intervention1: not applicable: not applicable

Eligibility

Inclusion criteria

Inclusion criteria: Both male and female, Age between 18 to 65 years old. Individuals declared Brain dead from a traumatic brain injury having diffuse axonal injury on MRI Not willing for organ donation Written informed consent from the legally acceptable representative of the patient

Exclusion criteria

Exclusion criteria: Metallic clips/ metal implants or intracranial implants in the brain. Pregnancy

Design outcomes

Primary

Measure	Time frame
Any evidence of reversal of brain death as noted in clinical examination or EEGTimepoint: day 0 to day 15 every day monitoring	—

Secondary

Measure	Time frame
Evaluation of clinical laboratory tests including CSF analysis and MRITimepoint: Day 0 to Day 15, everyday monotoring	—

Countries

India

Contacts

Public ContactDr Himanshu Bansal

Anupam Hospita

hbansal@drhbf.org9634501234

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026