Health Condition 1: K74- Fibrosis and cirrhosis of liver
Conditions
Interventions
Intervention1: ANTIBIOTIC -INJECTION CEFTRIAXONE: IN PATIENTS WITH CHILD A CIRRHOSIS PRESENTING TO EMERGENCY WITH ACUTE VARICEAL BLEED WILL BE RANDOMIZED TO EITHER CEFTRIAXONE ARM OR NO DRUG
Control I
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: All patients of Child-A cirrhosis presenting with Acute variceal bleed.
Exclusion criteria
Exclusion criteria: 1) Child-B/C cirrhosis 2) Child-A cirrhosis who have received antibiotics prior to randomisation 3) Child-A cirrhosis who have evidence of infection at presentation 4) Child- A cirrhosis with concomitant hepatocellular carcinoma (HCC) 5) Patients with overt hepatic encephalopathy at presentation 6) AVB in patients with ACLF 7) Patients with renal dysfunction at presentation (serum creatinine >1.5g/dl) 8) Pregnant and lactating females 9) Patients with age 10) COVID -19 positive patients. 11) Refusal to give consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of incidence of infections (SBP and non-SBP related) between those receiving and not receiving antibiotic prophylaxisin child A patients presenting with acute variceal bleed during the period of hospitalisation due to AVB.Timepoint: 72 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of the following outcomes between antibiotic treated and non-treated patients: 1) 6-week rebleed rate 2) 6-week mortality rate 3) Incidence of failure to control bleed during the index AVB Timepoint: 6 weeks | — |
Countries
India
Contacts
Public ContactANOOP SARAYA
ALL INDIA INSTITUE OF MEDICAL SCIENCES, NEW DELHI
Outcome results
None listed