Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: D- Radiation Therapy
Conditions
Interventions
Intervention1: Low dose Radiation.: Arm A will receive 0.7 Gy single fraction radiation to bilateral lungs along with institutional protocol.
Control Intervention1: No Radiation will be given only
Sponsors
All India Institute of Medical Sciences Patna
Eligibility
Inclusion criteria
Inclusion criteria: 1) Age >= 18 years 2) Patients with confirmed diagnosis of SARS-Cov2 infection by RT-PCR on nasopharyngeal swab and / or bronchoalveolar lavage (BAL) 3) Patients having MOHFW Moderate disease with SpO2 20 Breaths per minute on Room Air with fewer than 8 days of symptom onset and currently receiving standard medication for COVID-19 at appropriate doses. Covid-19 classification criteria led down by MOHFW, Govt. Of India (Appendix 1) 4) Suggestive picture finding for interstitial pneumonia on chest X-ray and / or chest CT (optional) 5) Ability to understand and sign informed consent. 6) Ability to acquire and maintain the set-up necessary for the delivery of radiotherapy treatment
Exclusion criteria
Exclusion criteria: 1) Patients with MOHFW defined severe disease. 2) Patients undergoing invasive mechanical ventilation. 3) Patients with active autoimmune systemic diseases. 4) Hemodynamically unstable patients. 5) Patients with a positive pregnancy test. 6) Impossibility to maintain the set-up necessary for radiotherapy treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective: To evaluate change from moderate to severe grade of disease in both the group with NEWS-2 Timepoint: Time Frame Day 1, Day 3, Day 7, Day 14 | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objective: To evaluate the changes in a. Change in physiological parameters including oxygen levels (PaO2 / FiO2), b. Change in laboratory testing WBC, platelets ESR, D-dimer, LDH, Ferritin, IL-6, CRP. c. Change in CECT Thorax that will be performed on follow up at 7 day and 28 days from baseline. Timepoint: Day 1.7.28 amd 6 months | — |
Countries
India
Contacts
Public ContactPritanjali singh
All India Institute of Medical Sciences Patna.
Outcome results
None listed