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TO COMPARE HAEMODYNAMIC STABILITY OF CLONIDINE AND MAGNESIUM SULPHATE DURING PNEUMOPERITONEUM IN LAPAROSCOPIC CHOLECYSTECTOMY

COMPARATIVE STUDY OF INTRAVENOUSLY ADMINISTERED CLONIDINE AND MAGNESIUM SULPHATE IN ATTENUATING HEMODYNAMIC RESPONSE TO PNEUMOPERITONEUM DURING LAPAROSCOPIC CHOLECYSTECTOMY RANDOMISED BLINDED COMPARATIVE STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/05/033894
Enrollment
68
Registered
2021-05-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K810- Acute cholecystitis Health Condition 2: K812- Acute cholecystitis with chronic cholecystitis Health Condition 3: K806- Calculus of gallbladder and bile duct with cholecystitis Health Condition 4: K807- Calculus of gallbladder and bile duct without cholecystitis Health Condition 5: K800- Calculus of gallbladder with acutecholecystitis Health Condition 6: K801- Calculus of gallbladder with othercholecystitis Health Condition 7: K802- Calculus of gallbladder without cholec

Interventions

Intervention1: clonidine: CLONIDINE 1.5 mcg/kg in 100 ml NS over 15 mins immediately after intubation in general anaesthesia and prior to creation of pneumoperitoneum Control Intervention1: Magnesium

Sponsors

Nazareth Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and ASA II Both gender in the agr group of 18-60 years Patients posted for elective laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: - Patients who refused to give informed written consent -Patients with known allergy to magnesium sulphate and clonidine - Pregnant patients posted for lapascopic cholecystectomy

Design outcomes

Primary

MeasureTime frame
Primary objective: The aim of this study will be to compare the effect of IV administered Clonidine and Magnesium sulphate on hemodynamic response during pneumoperitoneum in laparoscopic cholecystectomyTimepoint: 6 months—

Secondary

MeasureTime frame
comparison of adverse effects like hypotension, bradycardia(intra-operatively),nausea,vomiting,and shivering. Level of sedation immediately after extubation in both the groups will be assessed using Modified Ramsay Sedation ScoreTimepoint: 6 months—

Countries

India

Contacts

Public ContactDr Sharon Aylmer Lamare Rymbai

Private institute / organisation

himjyotidas@rediff.com9862018017

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026