Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Low dose radiotherapy to bilateral lungs for COVID-19 pneumonia - A Prospective Single Centre Study: Low dose radiotherapy using linear accelerator to bilateral whole lungs to a dose of
Sponsors
Kolhapur Cancer Centre
Eligibility
Inclusion criteria
Inclusion criteria: Patients with RT-PCR proven COVID-19 infection with moderate to severe pneumonia with National Early Warning Score [NEWS] 5 or more.
Exclusion criteria
Exclusion criteria: 1.Patients requiring mechanical ventilation 2.Prior lobectomy or pneumonectomy 3.Prior thoracic radiotherapy 4.Prior chemotherapy or other systemic therapy with potential for pulmonary toxicity 5.Prior radio-sensatization 6.Severe pre-existing heart disease e.g. New York Heart Association [NYHA] functional class 3 or higher, congestive cardiac failure 7.History of Bone marrow or solid organ transplant 8.Known history of autoimmune collagen vascular disease 9.Known hereditory syndrome with increased sensitivity to ionizing radiation e.g. ataxia-telengiectasia or Fanconi anemia 10.Pregnancy 11.Inability to lie down supine and flat for radiotherapy 12.Inability to provide informed consent or lack of authorized representative who can provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the clinical response of low dose radiotherapy to bilateral lungs in patients with COVID-19 pneumonia.Timepoint: Day 0,1,2,3,5,8,15 and 28 | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the safety of bilateral lung low dose radiotherapy, improvement in radiological parameters, improvement in laboratory parameters and mortality rate at 28 days after irradiationTimepoint: Day 1,2,3,5,8,15 and 28 | — |
Countries
India
Contacts
Public ContactReshma Pawar
Kolhapur Cancer Centre
Outcome results
None listed