Health Condition 1: B338- Other specified viral diseases Health Condition 2: B342- Coronavirus infection, unspecified Health Condition 3: B342- Coronavirus infection, unspecified
Conditions
Interventions
Intervention1: Doxycycline: Intention to treat with 200 mg oral doxycycline tablet qd for fourteen days on top of the standard of care (SOC).
Control Intervention1: Usual care: Standard care of COVID-
Sponsors
You Breathe We Care
Eligibility
Inclusion criteria
Inclusion criteria: Able to give informed consent • Male or female, age 40to 90 years • Typical symptoms of COVUD-19 infection: new onset of or exacerbation of cough due to chronic respiratory illness, dyspnea, Increased body temperature (forehead T° >37.6°C; oral T° >38°C; axillary >37.5°C) • SARS-CoV-2 infection demonstrated by PCR • Admission to hospital within 10 days of onset of symptoms
Exclusion criteria
Exclusion criteria: Hypersensitivity to doxycycline; myasthenia gravis; pregnancy; hepatic failure (CHILD-Pugh score C); unable to give informed consent
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| death, mechanical ventilation, time to discharge, recovery from symptoms, resolution of fever, prolonged hospital stay (7days), supplemental oxygen requiredTimepoint: Day zero to day 14. | — |
Primary
| Measure | Time frame |
|---|---|
| Admission to ICUTimepoint: Day zero to Day 14 | — |
Countries
India
Contacts
Public ContactDr Raja Dhar
YOU BREATHE WE CARE
Outcome results
None listed