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A study to compare two types of therapy in locally advanced gall bladder cancer: Chemotherapy combined with irreversible electroporation versus chemotherapy alone

Comparison of chemotherapy combined with percutaneous electroporation and chemotherapy alone in the management of locally advanced carcinoma of the gall bladder

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/05/033803
Enrollment
30
Registered
2021-05-25
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C23- Malignant neoplasm of gallbladder

Interventions

Intervention1: Chemotherapy combined with percutaneous irreversible electroporation(IRE): IRE will be done at presentation followed by chemotherapy (Gemcitabine and cisplatin) Follow-up imaging will b

Sponsors

SERB
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with unresectable malignant GB masses 2. Life expectancy of at least 3 months. 3. Size of tumor 4. Total bilirubin level < 2.5 mg/dl

Exclusion criteria

Exclusion criteria: 1. Uncorrectable coagulopathy 2. Patients with poor general condition and estimated life expectancy less than 3 months 3. Patients unfit for general anaesthesia 4. Presence of cardiac disease/arrhythmia/heart block 5. Presence of malignant ascites 6. Presence of metastatic disease

Design outcomes

Primary

MeasureTime frame
SurvivalTimepoint: One year—

Secondary

MeasureTime frame
Safety of the procedure Quality of lifeTimepoint: Safety of the procedure-baseline Quality of life-baseline and at 4 weeks—

Countries

India

Contacts

Public ContactNaveen Kalra

PGIMER

navkal2004@yahoo.com9855426320

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 6, 2026