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Role of autologous Platelet rich plasma in infertile females.

Intrauterine instillation of autologous Platelet rich plasma in infertile females with thin endometrium undergoing intrauterine insemination: a prospective interventional study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/05/033764
Enrollment
55
Registered
2021-05-24
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: N979- Female infertility, unspecified

Interventions

Intervention1: Intrauterine instillation of autologous platelet rich plasma(PRP) in infertile women with thin Endometrium undergoing intrauterine insemination (IUI).: Intrauterine instillation of auto

Sponsors

vmmc and safdarjung hospital delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Infertile female between 21-37 years. 2. Persistent thin endometrial thickness =1 cycle in previous cycle even after conventional treatment with estradiol valearate. 3. HB >11 gm% and platelets >1.5 lakhs

Exclusion criteria

Exclusion criteria: 1. History of symptoms of platelet dysfunction such as easy bruisability, frequent nose-bleeds, heavy menstrual bleeding, bleeding gums or excessive bleeding during dental procedures. 2. Blood borne disease like Hepatitis B, Hepatitis C, Syphilis, HIV. 3. NSAIDs intake in 10 days before the procedure 4. Pt on anticoagulant therapy 5. Severe Male factor for infertility 6. Tubal factor for infertility 7. WHO class 1 or 3 ovulatory dysfunction 8. Mullerian abnormality 9. Ashermann Syndrome 10. Moderate /severe endometriosis 11. Active vaginal/cervix infection/pelvic inflammatory disease. 12. Any significant co-morbidity/ psychiatric disorder which compromise or interfere with consent giving/study participation/ follow up or interpretation of study.

Design outcomes

Primary

MeasureTime frame
Primary Outcome 1)Change in endometrium thickness. 2)change in endometrium vascularity Timepoint: 36-40 hours post PRP instillation—

Secondary

MeasureTime frame
Secondary outcome 1)positive pregnancy rate 2).clinical pregnancy rate Timepoint: 1)positive pregnancy rate-14 DAYS after intrauterine insemination by urine pregnancy test. 2)clinical pregnancy rate-28 days after intrauterine insemination by transvaginal ultrasound.—

Countries

India

Contacts

Public ContactDr DIVYA PANDEY

Vardhman Mahavir Medical College and Safdarjung hospital,Delhi-110029.

dr_devya1@yahoo.co.in08860198440

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026