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Metformin usage leading to Vitamin B12 deficiency and complications arising from Vitamin B12 deficiency

Metformin Induced Vitamin B12 Deficiency

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/05/033755
Enrollment
205
Registered
2021-05-24
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Control Intervention1: NIL: NIL

Sponsors

Dr Sudha Vidyasagar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Type 2 Diabetics as per ADA guidelines Age 30-70 years On Metformin

Exclusion criteria

Exclusion criteria: History of alcohol consumption Pregnancy Patients with liver failure, chronic hepatitis Autoimmune Thyroid disease Patients suffering from malignancies Patients with Renal failure (Creatinine Clearance People suffering from bowel disorders such as â?? Atrophic gastritis, Pernicious anemia, IBD, Chronic Pancreatitis, Whippleâ??s disease, Parasitic Infections, Post bowel surgeries such as Gastrectomy, Terminal Ileal resection surgeries and Bariatric surgeries Patients treated for Vitamin B12 deficiency with a course of IV Vitamin B12

Design outcomes

Primary

MeasureTime frame
Occurrence of low Vitamin B12 levels in type 2 diabetics on metformin Occurrence of macrocytic anemia in type 2 diabetics on metformin occurrence of diabetic peripheral neuropathy in diabetics on metforminTimepoint: 1 YEAR 4 MONTHS—

Secondary

MeasureTime frame
Occurrence of macrocytic anemia in type 2 diabetics on metformin occurrence of diabetic peripheral neuropathy in diabetics on metforminTimepoint: 1 YEAR 4 MONTHS—

Countries

India

Contacts

Public ContactArjun Ballal

Kasturba Medical College

sudha.vs@manipal.edu7259123933

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026