Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: B338- Other specified viral diseases
Conditions
Interventions
Control Intervention1: REMDESIVIR: Remdesivir, usullay administered as injection at a loading dose of 200mg intravenously on Day 1 over 30 - 120 min, followed by 100mg for another 4 days for covid -19
Sponsors
Government of Tamilnadu
Eligibility
Inclusion criteria
Inclusion criteria: Age ââ?°Â¥12 years with Confirmed COVID-19. (Laboratory (RT-PCR) ââ?¬â?? Positive) Moderate COVID pneumonia: Moderate Pneumonia (frequent fever, cough) with no obvious hypoxemia, chest CT with lesions. Severe COVID pneumonia: Severe Pneumonia with hypoxemia (SpO2 Patients received Remdesivir (Case) and also not received it (Control group).
Exclusion criteria
Exclusion criteria: Mild infection (without CT lesions) Critical pneumonias (CT involvement > 75%). Patients with moderate and Severe pneumonia but died within 3 days of hospital admission. Patient who received Tocilizumab (critical pts) Severe liver disease (AST > 5 times upper limit) Patients with severe renal impairment (estimated GFR �30 mL/min/1.73 m2) or receiving continuous Dialysis Pregnant or breastfeeding mothers. Patient transferred to another hospital within 72 hours. Cases with inadequate datas.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Time to clinical recovery 2. All cause mortality Timepoint: one month | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Duration of invasive mechanical ventilation 2. Duration of noninvasive ventilation or use of high-flow Nasal oxygen devices (HFNO); 3. Duration of low-flow supplemental oxygen; 4. Any Complications (Drug or disease related), 5. Length of hospital stay (days) Timepoint: One month | — |
Countries
India
Contacts
Public ContactDuraisamy Kathirvel
Government Villupuram Medical College and Hospital
Outcome results
None listed