A clinical trial to study the effect of four intracanal medicaments in teeth with apical periodontitis

Synthesis,Characterization,Antimicrobial efficiency of Calcium hydroxide and Graphene based silver nanoparticle intra canal medicaments and their clinical validation- A Randomised Clinical Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/05/033716

Enrollment

Registered

2021-05-21

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: Calcium hydroxide and Graphene based silver nanoparticle: Silver has high affinity for negatively charged molecules within the bacterial cells , Inactivates critical functions of bacte

Eligibility

Inclusion criteria

Inclusion criteria: Non vital teeth with apical periodontitis

Exclusion criteria

Exclusion criteria: Medically compromised individuals, Vital teeth, Large periapical lesions, Endo-perio lesions, Age above 55 years

Design outcomes

Primary

Measure	Time frame
Reduction of microbial loadTimepoint: Baseline Values (S1) After cleaning and shaping of root canals (S2) After 7 days of medicament placement (S3)	—

Secondary

Measure	Time frame
Postoperative PainTimepoint: 4hrs,12hrs,24hrs,48hrs	—

Countries

India

Contacts

Public ContactV Vishnupriya

Saveetha Dental College,Saveetha University

drvishnupriyav@gmail.com9841445599

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026