Health Condition 1: A00-B99- Certain infectious and parasitic diseases
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
Dr Reddys Laboratories Ltd
Eligibility
Inclusion criteria
Inclusion criteria: Group-I 1. Participants in the age group of 3 to 5 years with a diagnosis of infections and advised five days or more of oral or intravenous antibiotics 2. Parents willing to provide written informed consent Group-II 1. Participants In the age group of 3 to 5 years attending clinics for vaccination, non-infectious diseases. 2. Parents willing to provide written informed consent
Exclusion criteria
Exclusion criteria: Group-I 1. Chronic illnesses including metabolic, neurological, allergic disorders 2. History of any other chronic illness, NICU & PICU admission 3. History of any acute childhood illness in the past week 4. History of drug intake in the last 3 months including antibiotics, PPIs, Probiotics Group-II 1. Chronic illnesses including metabolic, neurological, allergic disorders 2. History of any other chronic illness, NICU & PICU admission 3. History of any acute childhood illness in the past week 4. History of drug intake in the last 3 months including antibiotics, PPIs, Probiotics
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure the quantitative and qualitative differences in relative abundance of gut microbiota composition between Group I and Group II including: ? Phyla Firmicutes and Bacteroidetes, Firmicutes/Bacteroidetes Ratio ? Genera Lactobacillus, Bifidobacterium, Bacteroides, Prevotella, Enterobacter, Roseburia, Clostridium and Escherichia ? Microbial diversityTimepoint: Day 0 to Day 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| To measure the biologic function of genera and species by analyzing stool samples using amplicon based 16s rRNA sequencing methodTimepoint: Day 0 to Day 5 | — |
Countries
India
Contacts
Public ContactColette Pinto
Dr. Reddys Laboratories Ltd.
Outcome results
None listed