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A clinical trial to study the effects of two pain relief drugs, dexmedetomidine and buprenorphine added to levobupivacaine, a numbing drug injected below the curved front bone of the shoulder using an imaging machine in patients undergoing broken bone surgeries of upper extremity.

Comparison of analgesic efficacy of dexmedetomidine and buprenorphine as an adjuvant to levobupivacaine in patients undergoing fracture surgeries of upper limb performed under ultrasound guided infraclavicular block - a randomised control trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/05/033641
Enrollment
120
Registered
2021-05-17
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS- Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Buprenorphine as additive to infraclavicular levobupivacaine: 150 micrograms of buprenorphine(0.5ml) as additive to infraclavicular 0.5% levobupivacaine (29.5ml) for patients undergoi

Sponsors

Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I or II patients Age 18â??60 years, scheduled for surgeries of the forearm, wrist and hand under US-guided infraclavicular brachial plexus block

Exclusion criteria

Exclusion criteria: Patients aged 60 years. Patients having body weight 70 Kg. Any contraindication to regional anesthesia. Refusal for infraclavicular block and inability to give consent Patients undergoing surgeries of arm, elbow, shoulder Patients having peripheral neuropathy or hypersensitivity to local anaesthetic agents. Patients having history of seizures. History of pulmonary, cardiac, hematological, endocrinal, and neuromuscular disorders.

Design outcomes

Primary

MeasureTime frame
post operative analgesia using VAS pain scaleTimepoint: postoperative period 2nd,4th,6th,8th,12th,16th,20th,24th,28th,32nd,36th,40th,44th,48th hour—

Secondary

MeasureTime frame
Anticipated side effectsTimepoint: post operative period upto 48 hours;Hemodynamic parameters ( Heart rate, respiratory rate, systolic blood pressure,diastolic blood pressure, mean arterial pressure, oxygen saturation)Timepoint: baseline, 2 minutes, 4 minutes, 6 minutes, 8 minutes, 10 minutes, 15 minutes, 30 minutes, 45 minutes, 1 hour, 1.5 hours, 2 hours, 4 hours, 6 hours, 8 hours, 10 hours, 12 hours, 16 hours, 20 hours, 24 hours, 28 hours, 32 hours, 36 hours, 40 hours, 44 hours, 48 hours;Motor block ( onset of motor blockade and return to bromage score 0)Timepoint: post operative period upto 48 hours;Sensory block(complete loss of sensation to pin prick to return of sensation)Timepoint: post operative period upto 48 hours—

Countries

India

Contacts

Public ContactDr Sneka Priyadharsini V

Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research

drpathin2@gmail.com9787740890

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026