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Assessment of salivary Trefoil factor (TFF3) as an indicator in periodontitis patients.

Estimation of salivary Trefoil Factor (TFF3) as a biomarker in periodontitis patients-A Prospective clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/05/033596
Enrollment
44
Registered
2021-05-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: scaling and scaling and root planing: The patients with periodontitis and bleeding on probing less than 10% will undergo scaling and root planing and scaling as followed by collection

Sponsors

Dr Ritika Verma
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Group A- 1.Patients with the age group of 20-40 years. 2.Bleeding on Probing 3.No clinical attachment loss in at least 6 teeth. 4.Patient who is ready to maintain regular appointments. Group B-(Stage I-II Periodontitis) 1.Patients with age group of 20-40 years. 2.Patients with stage I-II Periodontitis with interdental CAL 1-4mm in atleast 6 teeth. 3.Probing Pocket Depth 4.Bleeding on Probing (BOP) >= 10%. 5.Patient who is ready to maintain regular appointments

Exclusion criteria

Exclusion criteria: 1.Pregnant or lactating women 2.Patients with systemic diseases. 3.Patients who have used antibiotics in past 3 months 4.Patients who have received periodontal treatment in past 3 months. 5.Patient currently on nonsteroidal anti-inflammatory analgesics. 6.Patients with a history of smoking 7.Patients with a history of salivary gland diseases. 8.Patients with wasting diseases where cemento-enamel junction is not visible.

Design outcomes

Primary

MeasureTime frame
1.To assess salivary Trefoil Factor (TFF3) levels using ELISA and clinical parameters in healthy patients. 2.To assess Salivary Trefoil Factor (TFF3) levels using ELISA and clinical parameters in Stage I-II Periodontitis patients. Timepoint: At Baseline(first visit), 1 month and 3 months.

Secondary

MeasureTime frame
To compare and evaluate the salivary Trefoil Factor levels using ELISA and clinical parameters in Healthy and Stage I-II Periodontitis patients.Timepoint: At Baseline(first visit), 1 month and 3 months.

Countries

India

Contacts

Public ContactDr Ritika Verma

Manav Rachna Dental College

pooja.mrdc@mrei.ac.in09891175112

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026