To compare the effects of a conventional and an advanced mode of ventilator on surgical patients admitted in ICU

A comparison of ventilatory and cardiopulmonary variables in surgical patients undergoing synchronized intermittent mandatory ventilation-volume control and pressure-regulated volume control in intensive care unit.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/05/033595

Enrollment

106

Registered

2021-05-13

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Pressure regulated volume control mode of ventilation: After putting the patient on PRVC mode ventilatory and cardiopulmonary variables would be assessed at specific time points. Contro

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients on invasive mechanical ventilation and admitted in ICU following exploratory laparotomy due to ARF for less than 24 hours 2.Age group 18-60 years 3.Stable hemodynamic parameters (Mean Arterial Pressure between 70 mm Hg - 100 mm Hg, Heart Rate between 60 - 100/minute, SPO2 >= 90%) 4.Richmond Agitationâ??Sedation Scale (RASS)between 0 and -2

Exclusion criteria

Exclusion criteria: 1.Refusal of informed consent 2.Pregnant women 3.Morbidly obese patients (BMI >35) 4.Patients diagnosed with ARDS (Mild, Moderate or Severe) according to Berlinâ??s definition. 5.Patients with severe or chronic heart, lung, hepatic or renal disease 6.Patients with severe neuromuscular disorders 7.Patients on vasopressors, cardiac depressants or neuromuscular blockers 8.Patients with traumatic brain injury 9.Patients with blunt or traumatic chest injury 10.Patients with severe multiple organ dysfunction.

Design outcomes

Primary

Measure	Time frame
Ventilatory Parameters ( Peak airway pressure, Platue pressure, Mean airway pressure, Mean airway pressure, Compliance, Static compliance, Airway resistance)Timepoint: T1-Two hours after keeping on A/C VC mode just before switching to study mode (as per group allocation). T2-Four hours after switching on study mode T3-Twelve hours after switching on study mode	—

Secondary

Measure	Time frame
1) Haemodynamic Parameters- Systolic Blood Pressure, Diastolic Blood Pressure, mean Arterial Pressure, End Tidal Carbon Dioxide, Oxygen Saturation as per Pulse Oximetry. 2) Arterial Blood Gas Analysis Parameters- Partial Pressure of Oxygen in Arterial Blood, Partial Pressure of Carbon Dioxide in Arterial Blood, Oxygen Saturation in Arterial Blood, pHTimepoint: T1-Two hours after keeping on A/C VC mode just before switching to study mode (as per group allocation). T2-Four hours after switching on study mode T3-Twelve hours after switching on study mode	—

Measure

Time frame

1) Haemodynamic Parameters- Systolic Blood Pressure, Diastolic Blood Pressure, mean Arterial Pressure, End Tidal Carbon Dioxide, Oxygen Saturation as per Pulse Oximetry. 2) Arterial Blood Gas Analysis Parameters- Partial Pressure of Oxygen in Arterial Blood, Partial Pressure of Carbon Dioxide in Arterial Blood, Oxygen Saturation in Arterial Blood, pHTimepoint: T1-Two hours after keeping on A/C VC mode just before switching to study mode (as per group allocation). T2-Four hours after switching on study mode T3-Twelve hours after switching on study mode

—

Countries

India

Contacts

Public ContactDr Deepanshu Rai

Government Medical College and Hospital, Sector 32, Chandigarh

kapoor.dheeraj72@gmail.com9646121549

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026