Health Condition 1: K053- Chronic periodontitis Health Condition 2: E116- Type 2 diabetes mellitus with other specified complications
Conditions
Interventions
None listed
Sponsors
AKSHAYA J
Eligibility
Inclusion criteria
Inclusion criteria: Based on 2017 World Workshop on the Classification of Periodontal and Peri-implant diseases and conditions, co-presented by the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP), Inclusion criteria for Healthy group: 1.Pristine periodontal health: i. No bleeding on probing. ii. Normal gingival sulcus depth. iii. Normal bone heights. iv. Controlled modifying factors. v. Controlled predisposing factors. 2.Clinical periodontal health (intact periodontium): i. No or minimal bleeding on probing. ii. Normal gingival sulcus depth. iii. Normal bone heights. iv. Controlled modifying factors. v. Controlled predisposing factors. Inclusion criteria for Gingivitis group: i. Absence of CAL ii. PPD iii. BOP present Inclusion criteria for Stage III/IV Periodontitis: According to the new classification scheme (Kornman and Tonetti et al, 2018). 1.Stage III: i. Interdental clinical attachment loss at site of greatest loss >= 5mm. ii. Radiographic bone loss extending to middle or apical third of root iii. Tooth loss due to periodontitis iv. Probing depth >= 6mm. v. Extent: Greater than 30% of teeth involved (Generalized) 2.Stage IV: i. Interdental clinical attachment loss at site of greatest loss >= 5mm. ii. Radiographic bone loss extending to middle or apical third of root iii. Tooth loss due to periodontitis >= 5 teeth. iv. Extent: Greater than 30% of teeth involved (Generalized) Inclusion criteria for Type 2 Diabetes mellitus 1. Patients with HbA1c levels more than 8% will be taken for the study in the groups involving Diabetes. (According to American Diabetes Association guidelines 2018)
Exclusion criteria
Exclusion criteria: 1. Pregnant women 2. Pregnant and lactating women. 3. Habits like tobacco ,smoking 4. Patients with immunodeficiency disorders. 5. Patients with other systemic inflammatory conditions like sepsis, pneumonia, pleural effusion, intra-abdominal infections, inflammatory bowel disorders, inflammatory rheumatoid disorders, chronic kidney disease, cancers, atherosclerosis, COPD, asthma, HIV and hepatitis will be excluded from the study. 6. Patients with systemic diseases like hypertension 7. History of periodontal treatment within the previous 6 months. 8. History of antibiotic therapy in the past 3 months. 9. Subjects who are not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantify the levels of the salivary macrophage polarization biomarkers â?? sCD163, NITRIC OXIDE, and Mi RNA-21 in health, in gingivitis and in periodontitis patients with and without a systemic risk factor â?? Diabetes Mellitus Timepoint: baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlate between various macrophage polarisation markers in various study groups Timepoint: baseline | — |
Countries
India
Contacts
Public ContactDr AKSHAYA J
SRM DENTAL COLLEGE
Outcome results
None listed