Health Condition 1: A415- Sepsis due to other Gram-negativeorganisms
Conditions
Interventions
None listed
Sponsors
Manipal Center for Infectious Diseases MAC ID
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with sepsis or septic shock: suspicion of infection and microbiological sampling undertaken, received meropenem, vasopressor therapy needed to elevate mean arterial pressure >=65 mmHg and lactate >2mmol/L (18mg/dL) despite adequate fluid resuscitation 2. Confirmed infection by Gram negative organism (Klebsiella pneumoniae, Escherichia coli and/or Pseudomonas aeruginosa)
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women 2.Documented hypersensitivity to carbapenems 3.Patients with an anticipated hospitalization of 4.Patients with chronic kidney disease (CKD) 5.Extra-corporeal circulation in the month preceding inclusion in the case of cardiac surgery 6.Blood transfusion >4 units in past week 7.Patient with restricted liberty or under legal protection 8.Inability to consent the patient or next of kin 9.Second admission to ICU or previous enrolment in study (within same hospital admission) 10.Transfer from other hospital ICUs (if stay >24 hrs)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outline of the population pharmacokinetic (pop-PK) parameters An understanding of the effectiveness of standard dosing regimens on patients with sepsisTimepoint: 3 different time points | — |
Secondary
| Measure | Time frame |
|---|---|
| To identify the probable reasons for insufficient usage of meropenem in the clinical setting of Gram-negative sepsis while they show in-vitro susceptibility Timepoint: 3 time points | — |
Countries
India
Contacts
Public ContactAnna R Thomas
Kasturba Medical College, Manipal
Outcome results
None listed