Health Condition 1: E049- Nontoxic goiter, unspecified
Conditions
Interventions
Intervention1: Melatonin: One group of patients will be given Tab melatonin 6mg orally, 120 minutes before surgery. The drug will be given only once
Control Intervention1: Placebo: One group of patien
Sponsors
Amrita Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing total thyroidectomy ASA PS â?? I and II
Exclusion criteria
Exclusion criteria: 1. Anticipated difficult airway, 2. Those requiring >1 attempt or >15sec for laryngoscopy, use of bougie 3. BMI >30 kg/m2, 4. patients on antipsychotic, sedatives, anxiolytics and antiepileptic drugs, rate controlling medications 5. Known allergy to melatonin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare heart rate response at 1 min after intubation in patients following oral premedication with melatonin versus placebo 2 hours before surgery.Timepoint: At one minute after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in heart rate, blood pressure, intraoperative requirement of fentanyl and isoflurane, preoperative and postoperative sedation will be comparedTimepoint: before and after premedication, before and after induction,1, 3, 5 and 10 min following intubation and after surgery | — |
Countries
India
Contacts
Public ContactDr Reema Abubaker
Amrita Institute of Medical Sciences
Outcome results
None listed