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Assessing the role of serum cortisol and Aβ42 in the prediction of early onset Alzheimers Disease in patients with Generalized Anxiety Disorders and Stage III/IV periodontitis.

ROLE OF SERUM CORTISOL AND Aβ42  IN THE PREDICTION OF EARLY ONSET ALZHEIMERS DISEASE IN PATIENTS WITH GENERALISED ANXIETY DISORDERS AND STAGE III/IV PERIODONTITIS

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/05/033422
Enrollment
56
Registered
2021-05-06
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

None listed

Sponsors

JEYVARSHINI K
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria for healthy individuals: According to the new classification scheme (Kornman and Tonetti et al, 2018). Pristine periodontal health: No bleeding on probing. Normal gingival sulcus depth. Normal bone heights. Controlled modifying factors. Controlled predisposing factors. 2.Clinical periodontal health (intact periodontium): No or minimal bleeding on probing. Normal gingival sulcus depth. Normal bone heights. Controlled modifying factors. Controlled predisposing factors. Inclusion criteria for Stage III/IV Periodontitis: According to the new classification scheme (Kornman and Tonetti et al, 2018). 1.Stage III: Interdental clinical attachment loss at site of greatest loss >= 5mm. Radiographic bone loss extending to middle or apical third of root Tooth loss due to periodontitis Probing depth >= 6mm. Extent: Greater than 30% of teeth involved (Generalized) 2.Stage IV: Interdental clinical attachment loss at site of greatest loss >= 5mm. Radiographic bone loss extending to middle or apical third of root Tooth loss due to periodontitis >= 5 teeth. Extent: Greater than 30% of teeth involved (Generalized) Inclusion criteria for Generalized Anxiety Disorders Ability to provide details for DASS21 questionnaire DASS21 score demonstrating moderate and severe depression or anxiety or stress Patients with no other medical complications. For depression: moderate score 14-20 and severe score 21-27 For anxiety: moderate score 10-14 and severe score 15-19 For stress: moderate score 19-25 and severe score 26-33

Exclusion criteria

Exclusion criteria: History of periodontal treatment within the previous 6 months. Smoking and alcohol consumption Pregnant and lactating women. History of antibiotic therapy in the past 3 months. Patients with any other systemic inflammatory conditions.

Design outcomes

Primary

MeasureTime frame
To assess the level of Aβ42 in the serum of patients with and without Generalized Stage III/IV Periodontitis and generalized anxiety disorders. To assess the levels of cortisol in serum of patients with and without Generalized Stage III/IV Periodontitis and generalized anxiety disorders. Timepoint: At baseline—

Secondary

MeasureTime frame
To correlate the serum levels of Aβ42 ,cortisol and clinical parameters of periodontal inflammation with the risk of developing early onset Alzheimers Disease.Timepoint: At baseline—

Countries

India

Contacts

Public ContactDr PRIYANKA K CHOLAN

SRM DENTAL COLLEGE

priyankacholan@gmail.com9840771507

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026