To compare the effects of airway pressure release ventilation and pressure control ventilation modes of ventilation on patients admitted in ICU requiring ventilator support

A comparison of ventilatory and cardiopulmonary variables in patients undergoing pressure control ventilation and airway pressure release ventilation in intensive care unit

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/05/033420

Enrollment

Registered

2021-05-06

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J962- Acute and chronic respiratory failure

Interventions

Intervention1: Airway pressure release ventilation(APRV)mode of ventilation.: After putting the patient on APRV mode, ventilatory and cardiopulmonary variables will be assessed at specific time points

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patient on invasive mechanical ventilation in ICU for less than 24 hours 2) Stable hemodynamic parameters(Mean Arterial Pressure between 70-100mmHg, Heart Rate between 60-100/minute, SPO2-90%) 3) Richmond Agitation Sedation Scale between 0 and -2 4)Age group 18-60 years

Exclusion criteria

Exclusion criteria: 1)Refusal of informed consent 2)Pregnant women 3)Morbidly obese patients (BMI > 35) 4)Patients diagnosed with ARDS (mild, moderate or severe) 5)Patients with severe or chronic heart, lung, hepatic, renal disease or neuromuscular disorder 6)Patient on vasopressor, cardiac depressants or neuromuscular blockers 7)Patients with traumatic brain or chest injury 8)Patients with severe multiple organ dysfunction

Design outcomes

Primary

Measure	Time frame
Ventilatory parameters(Peak airway pressure, Platue pressure, Mean airway pressure, Complaince, Static compliance, Airway resistance)Timepoint: T1- 60 minutes after keeping on SIMV-VC corresponding to time just before switching to study ventilator mode 1 as per allocation. T2- 60 minutes after keeping on ventilator mode 1 T3- 60 minutes after switching back on SIMV-VC corresponding to time just before switching to study ventilator mode 2. T4- 60 minutes after keeping on ventilator mode 2	—

Measure

Time frame

Ventilatory parameters(Peak airway pressure, Platue pressure, Mean airway pressure, Complaince, Static compliance, Airway resistance)Timepoint: T1- 60 minutes after keeping on SIMV-VC corresponding to time just before switching to study ventilator mode 1 as per allocation. T2- 60 minutes after keeping on ventilator mode 1 T3- 60 minutes after switching back on SIMV-VC corresponding to time just before switching to study ventilator mode 2. T4- 60 minutes after keeping on ventilator mode 2

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Secondary

Measure	Time frame
1)Haemodynamic parameters-Systolic blood pressure,Diastolic blood pressure,Mean arterial blood pressure,Heart rate,End -tidal cardon dioxide,Arterial oxygen saturation. 2)Arterial blood gas analysis parameters- pH, Partial pressure of oxygen, Partial pressure of carbon dioxide, Arterial oxygen saturation.Timepoint: T1-60 minutes after keeping on SIMV-VC corresponding to time just before switching to study ventilator mode 1(as per group allocation) T2- 60 minutes after keeping on ventilator mode 1 T3- 60 minutes after switching back on SIMV-VC corresponding to time just before switching to study ventilator mode 2 T4- 60 minutes after keeping on ventilator mode 2	—

Measure

Time frame

1)Haemodynamic parameters-Systolic blood pressure,Diastolic blood pressure,Mean arterial blood pressure,Heart rate,End -tidal cardon dioxide,Arterial oxygen saturation. 2)Arterial blood gas analysis parameters- pH, Partial pressure of oxygen, Partial pressure of carbon dioxide, Arterial oxygen saturation.Timepoint: T1-60 minutes after keeping on SIMV-VC corresponding to time just before switching to study ventilator mode 1(as per group allocation) T2- 60 minutes after keeping on ventilator mode 1 T3- 60 minutes after switching back on SIMV-VC corresponding to time just before switching to study ventilator mode 2 T4- 60 minutes after keeping on ventilator mode 2

—

Countries

India

Contacts

Public ContactDr Ramandeep Kaur

Government Medical College and Hospital, Sector 32, Chandigarh

kapoor.dheeraj72@gmail.com9646121549

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026