Health Condition 1: 1- Obstetrics
Conditions
Interventions
Intervention1: Pre operative administration of mephentermine or placebo before spinal anaesthesia: Preoperative administration intravenous mephentermine in one group along with intramuscular placebo,
Sponsors
Office of the Principal Midnapore Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: All pregnant mothers posted for lower segment caesarean section under spinal anaesthesia and can give informed consent for participation.
Exclusion criteria
Exclusion criteria: i. Less than 18 years of age ii. ASA grade III & above iii. More than 35 years of age iv. Having 2 lower segment caesarean section previously v. Having systolic blood pressure more than 140 mm Hg or diastolic blood pressure more than 90 mm Hg pre operatively vi. On anti-hypertensive medication(s) vii. Patients having gestational diabetes mellitus viii. Having Twin or multifetal pregnancy ix. Refusing to give consent x. Any cases where repeat spinal administration will be needed (Failed Spinal). xi. Any cases which may be needed to be converted in to general anaesthesia xii. Contraindication to spinal anaesthesia xiii. Patients having severe pallor xiv. Any operation lasting for more than 90 minutes xv. Foetal malformation or malpresentation xvi. Drug allergy to study drugs xvii. Any cases which require other rescue vasopressors during the procedure xviii. Emergency cases like 1. Foetal bradycardia 2. Impending rupture 3. heart disease 4. ante partum haemorrhage 5. Cord prolapses
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidences of hypotension among the study groups receiving pre operative mephentermine by intravascular route or intramuscular group to the placebo groupTimepoint: After administration of the drugs and spinal anaesthesia, data will be recorded for blood pressure, heart rate, saturation, ECG changes at 5minutes interval in intra-operative period for first 30 minutes, 10minutes for the remaining intraoperative period and 2 hours post-operatively. Pre operative vitals will be taken as baseline. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other parameters includes cumulative drug doses required in the groups and amount of ST changes in the intra-operative periodTimepoint: Same as that for Primary outcomes, that is at every 5 minutes interval for first 30 minutes and then every 10 minutes interval for the remaining intra operative period | — |
Countries
India
Contacts
Public ContactArun Kumar Mandi
Midnapore Medical College and Hospital
Outcome results
None listed