Health Condition 1: G437- Chronic migraine without aura Health Condition 2: G438- Other migraine
Conditions
Interventions
Intervention1: group 1 -amitriptyline and topiramate combination: topiramate will be prescribed 25 mg daily in ist week then increased to 25 mg weekly upto 100 mg daily .amitriptyline will be started
Sponsors
Principal Investigator Prof Jayantee Kalita
Eligibility
Inclusion criteria
Inclusion criteria: patients with chronic migraine attending neurology service will be included diagnosis of chronic migraine will be based on ICHD-3 beta criteria (2013)- adults >18 to h/o at least 8 attacks of migraine (with or without aura )per month in last 3 months h/o >15 headache days per month for >3 months history of migraine (with or without aura)for >12 months prior to enrollment
Exclusion criteria
Exclusion criteria: patients with uncontrolled diabeties/hypertension ,heart diseases,psychiatric disease,seizures,hearing deficit,ear disease,visual deficit,stroke like illness,infection,organ failure,malignancy,asthamatics,immunosuppressant,systemic disease,age 55 years ,migraine onset after 50 years of age ,on prophylactic treatment in past one month ,abortive medication with opioid drugs,pregnancy,and unwilling for consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| primary outcome-more than 50% reduction in headache days secondary outcome- severity in vas score number of abortive medication mMIDAS SCORE Migraine physical function impact diary severe adverse eventsTimepoint: base line ,ist and 3rd month | — |
Secondary
| Measure | Time frame |
|---|---|
| severity in vas score number of abortive medication mMIDAS SCORE Migraine physical function impact diary severe adverse eventsTimepoint: baseline ,ist and 3rd month | — |
Countries
India
Contacts
Public ContactABHISHEK
SGPGIMS
Outcome results
None listed