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Benefits of two locally delivered agents on cytokine levels in smokers with chronic periodontitis.

EFFICACY OF CURCUMIN GEL Vs HYALURONIC ACID GEL AS ADJUVANTS TO SCALING AND ROOT PLANING ON IL-1 beta LEVELS IN SMOKERS WITH CHRONIC PERIODONTITIS.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/05/033333
Enrollment
36
Registered
2021-05-03
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: Z779- Other contact with and (suspected)exposures hazardous to health

Interventions

Intervention1: Group 1 consisting of 12 patients who are current smokers with periodontitis wherein scaling and root planing will be done at baseline: After scaling and root planing 6 patients will re

Sponsors

PANINEEYA INSTITUTE OF DENTAL SCIENCES AND RESEARCH CENTRE
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with history of smoking Current smokers - patients who smoke more than 5 cigarettes per day per the past one month Former smokers - patients who used to smoke more than 5 cigarettes per day and have quit the habit for the past one month Patients with chronic periodontitis with 20 teeth remaining and probing pocket depth more than 5mm in one or more sites

Exclusion criteria

Exclusion criteria: Pregnant and lactating women Systemically compromised patients use of medicines or antibiotics 3 months before the enrollment History of periodontal treatment within 6 months

Design outcomes

Primary

MeasureTime frame
Estimation of interleukin 1 beta levels in gingival crevicular fluid Timepoint: Baseline and 6 weeks after scaling and root planing

Secondary

MeasureTime frame
Estimation of clinical parameters like plaque index and probing pocket depth will be assessed with williams probeTimepoint: Baseline , 8 weeks and 12 weeks after scaling and root planing;Estimation of interleukin 1 beta by ELISATimepoint: At baseline and 6 weeks after scaling and root planing

Countries

India

Contacts

Public ContactLaxmi Jaahnavi Devarampati

panineeya institute of dental sciences and research centre

rekhasarat2304@gmail.com9885160094

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026