Health Condition 1: K639- Disease of intestine, unspecified
Conditions
Interventions
Intervention1: Group L (Lignocaine group): Group L will receive iv lignocaine bolus of 1.5mg/kg at the induction of the anesthesia followed by infusion of 1.5mg/kg/hr intraoperatively .
Intervention2:
Sponsors
Dr S N Medical College Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: ASA I and II with lower abdominal surgery under general anesthesia, surgical time up to 2 hours.
Exclusion criteria
Exclusion criteria: Patients planned for postoperative mechanical ventilation or regional anesthesia/analgesia, perioperative gabapentin, magnesium, or nitrous oxide use, pregnancy or breastfeeding, morbid obesity (BMI >= 35 kg/m2 ), allergy to study medications, contraindication to lidocaine (severe cardiac arrhythmia) or ketamine (psychiatric disorder, substance abuse, uncontrolled hypertension, pulmonary hypertension, increased intracranial or intraocular pressure, use of MAO inhibitors), chronic preoperative opioid use (>= 90 morphine mg equivalents per day for > 3 months), significant preoperative hepatic dysfunction (ALT or AST > 5 times normal or planned liver transplantation), preoperative cardiac failure (left ventricular ejection fraction <= 40%), unable to communicate study instructions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare total mean opioid consumption(fentanyl) in first 24 hours postoperatively in three groups receving lignocaine, ketamine and normal saline.Timepoint: first 24 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.VAS scores 2.Time to request first analgesic after surgery 3.Hemodynamic parameters 4.Post-operative hospital length of stay (days). 5.Adverse effects Timepoint: 24 hours | — |
Countries
India
Contacts
Public ContactDr Jyoti Sharma
Dr. S.N. medical collage, Jodhpur
Outcome results
None listed