Health Condition 1: D180- Hemangioma
Conditions
Interventions
Intervention1: timolol: 0.25 to 0.50% hydrogel, Local application,
once daily for 24 weeks
Control Intervention1: Propranolol: Tablet Propranolol with starting dose of 0.5mg/kg/day (Orally) in two di
Sponsors
Varun Gupta
Guru GobinD Singh Medical College And Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1. Children diagnosed with problematic infantile haemangioma, defined a) Potentially disfiguring infantile haemangioma at any site. b) Functionally threatening infantile haemangioma near the eyes, nose, natural orifices, limbs & genitalia. c) Segmental infantile haemangioma. d) Uncomplicated progressive infantile haemangioma. 2. Either sex. 3. Multiple haemangiomas.
Exclusion criteria
Exclusion criteria: Exclusion criteria 1. Infants with heart disease, cardiac arrhythmias. 2. Broncho-obstructive disease. 3. Premature infants with corrected age less than 40 weeks. 4. Known hypoglycaemia. 5. Hypertension. 6. Hypotension. 7. Pediatric patients who have deranged LFT. 8. Visceral haemangiomas. 9. PHACES syndrome (Posterior fossa brain malformations, Hemangioma, Arterial lesions, Cardiac abnormalities, and Eye abnormalities). 10. Ulcerative haemangiomas. 11. Previously treated patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the size of superficial Infantile haemangioma Timepoint: 0 week, 4wks, 8wks, 12wks, 16wks, 20wks, 24wks, 28wks, 32wks. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the adverse event seen with the study drugs. To assess the increase or decrease of size of haemangiomaTimepoint: 0 week, 4wks, 8wks, 12wks, 16wks, 20wks, 24wks, 28wks, 32wks. | — |
Countries
India
Contacts
Public ContactAshish chhabbra
Guru Gobind Singh Medical College and hospital Faridkot
Outcome results
None listed