Effect of TOPICAL LIGNOCAINE AND DEXMEDETOMIDINE on POST OPERATIVE SORE THROAT AFTER GENERAL ANESTHESIA

The effect of direct instillation of combined lignocaine with dexmedetomidine in comparison to lignocaine alone on attenuation of postoperative sore throat in adult patients undergoing general anesthesia with tracheal intubation: A prospective randomized double blind study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/04/033270

Enrollment

260

Registered

2021-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: lignocaine and dexmedetomidine instillation over glottis to attenuate postoperative sorethroat after tracheal intubation: 2% lignocaine with 0.25ml dexmedetomidine will be directly ins

Eligibility

Inclusion criteria

Inclusion criteria: ASA-PS I-III patients,scheduled to undergo elective surgery under general endotracheal anesthesia and nasogastric intubation.

Exclusion criteria

Exclusion criteria: pre-existing steroid or NSAID use, preoperative sorethroat or upper airway infection, asthma, chronic obstructive pulmonary disease, pregnant and lactating women, known or suspected difficult airway, known allergies to study drug, smoker,not willing to give consent

Design outcomes

Primary

Measure	Time frame
risk of postoperative sore throat at 1,6 and 24 hours after the tracheal extubationTimepoint: risk of postoperative sore throat at 1,6 and 24 hours after the tracheal extubation	—

Secondary

Measure	Time frame
severity of postoperative sorethroat, severity of postoperative cough, severity of postoperative hoarseness graded on four point scaleTimepoint: 1,6 and 24 hours after tracheal extubation	—

Countries

India

Contacts

Public ContactDr Aloka Samantaray

svims

aloksvims@gmail.com9493547653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026