Health Condition 1: O10-O16- Edema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention1: Enalapril: Antihypertensive drug-Angiotensin converting enzyme inhibitor
dose and frequency-starting dose 2.5 mg twice daily upto 10 mg twice daily.
route of administration-oral
duratio
Sponsors
Internal Fluid Research
Eligibility
Inclusion criteria
Inclusion criteria: •Postnatal women with new onset hypertension( blood pressure >= 140 mm Hg systolic or >=90mmHg diastolic) •Women who had been diagnosed with intrapartum hypertension, treated with single short acting antihypertensive , during postnatal monitoring found to have blood pressure >= 140 mm Hg systolic or >=90mmHg diastolic. •Women who had been on single antihypertensive before pregnancy which was stopped postnatally and later detected to have hypertension after the wash out period of first drug.
Exclusion criteria
Exclusion criteria: •Women with severe intrapartum hypertension or gestational hypertension requiring >=1 antihypertensives. •Women who were already on antihypertensive drugs antenatally and the same continued postnatally •Women with creatinine >1.4 mg/dl •Women with urine output •Women with known heart block, cardiac failure or heart rate •Allergy to labetalol or enalapril •Moderate, persistent or severe asthma •Women with hyperkalemia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| â?¢To determine the proportion of women who would achieve adequate blood pressure control with the study drug. Timepoint: At the time of discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢Percentage reduction in systolic BP â?¢Percentage reduction in diastolic BP â?¢Need for other oral antihypertensive drugs â?¢Need for intra venous antihypertensive drugs â?¢Post partum complications secondary to hypertensive disorders of pregnancy-acute pulmonary oedema/ eclampsia/oliguria â?¢Drug reactions Time taken to discharge from the hospital â?¢BP and Need for antihypertensives at 6 weeks â?¢BP and Need for antihypertensives at 12 weeksTimepoint: 2 weeks | — |
Countries
India
Contacts
Public ContactDr Kavitha Abraham
Christian Medical College
Outcome results
None listed