FindTrial
Sign In

To compare the effect of mannitol and hypertonic saline on cardiac output in elderly patients

Comparison of the Effect of Mannitol(20%) and Hypertonic Saline (3%) on advanced hemodynamic parameters in geriatric patients undergoing neurosurgical procedures: A Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/04/033185
Enrollment
30
Registered
2021-04-28
Start date
Unknown
Completion date
Unknown
Last updated
2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Hypertonic saline (3%): Osmotic agent used to decrease intracranial pressure Intervention2: Mannitol (20%): Osmotic agent used to decrease intracranial pressure Control Intervention1: M

Sponsors

Post graduate institute of medicaleducation and research chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age above 60 years Undergoing craniotomy under general anaesthesia Requiring intraoperative osmotherapy Asa 1 and 2

Exclusion criteria

Exclusion criteria: Consent refusal Contraindications to insert transoesophageal echocardiography probe : osephageal surgery, strictures Patients with coronary artery disease/valvular heart disease Patients with end organ dysfunction Patients with hypo/hypernatremia and treated with mannitol or hypertonic saline in the previous 24hrs

Design outcomes

Primary

MeasureTime frame
Assessment of the left ventricular output by measuring left ventricle outflow tract velocity time integral using transoesophageal echocardiography after adminstration of mannitol and hypertonic salineTimepoint: Assessment of the left ventricular output by measuring left ventricle outflow tract velocity time integral using transoesophageal echocardiography after adminstration of mannitol and hypertonic saline at 5,15,30,45,60,90 mins post adminstration—

Secondary

MeasureTime frame
To compare brain relaxation score between two groups by surgeon before and after dural opening To compare heart rate and blood pressure change after study drug adminstration To study and compare serum electrolytes,serum osmolarity between two groups To note total duration of hospital stay To compare neurological outcome in both groups by mrs at discharge and 3 months. Timepoint: 1. BRS- before and after dural opening 2.Heart rate and blood pressure- Intraoperatively 5, 15,30,45,60, 90 mins post study drug adminstration 3. mRs -at discharge and 3 months after discharge—

Countries

India

Contacts

Public Contactashwini reddy

Postgraduate Institute of Medical Education and Research

nidhibp@gmail.com9900120148

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026