Effect of intravenous fluid administration on urinary kidney injury markers in pregnant women with high blood pressure undergoing caesarean section.

Effect of perioperative intravenous fluid administration with normal saline versus lactated ringer on urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) in preeclamptic women undergoing caesarean section- A randomized controlled trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/04/033169

Enrollment

120

Registered

2021-04-27

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 1- Obstetrics Health Condition 2: O14- Pre-eclampsia

Interventions

Intervention1: Ringers lactate: One set of study participants will recieve Ringers lactate as perioperative intravenous fluid therapy until oral resumed.Urine samples will be collected baseline and a

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age more than 18 years 2.Women with preeclampsia undergoing either elective or emergency caesarean section under spinal anaesthesia

Exclusion criteria

Exclusion criteria: 1.Preeclamptic women on restrictive fluid strategies such as those with pulmonary edema or cardiac failure (NYHA III and IV) 2.Pre-existing kidney disease 3.AKI as per KDIGO guidelines 4.HELLP syndrome

Design outcomes

Primary

Measure	Time frame
To study the difference in urinary NGAL and KIM-1 levels at three different time intervals (baseline from initiation of intravenous fluids, 6hrs, 12 hours postoperatively) during peri-operative administration of normal saline vs ringer lactate among pre-eclamptic women undergoing cesarean section.Timepoint: Baseline before initiation of intravenous fluids, 6hrs, 12 hours after caesarean section	—

Secondary

Measure	Time frame
1.To determine the correlation between urinary NGAL and KIM-1 with type and amount of fluids, severity of pre-eclampsia, admission systolic and diastolic BP. 2.To assess any difference in pH, bicarbonate and chloride levels at 12 hours and serum Creatinine at 48 hours postoperatively between two groups. Timepoint: To assess any difference in pH, bicarbonate and chloride levels at 12 hours by Arterial blood gas analysis and se. Creatinine at 48 hours postoperatively between two groups.	—

Measure

Time frame

1.To determine the correlation between urinary NGAL and KIM-1 with type and amount of fluids, severity of pre-eclampsia, admission systolic and diastolic BP. 2.To assess any difference in pH, bicarbonate and chloride levels at 12 hours and serum Creatinine at 48 hours postoperatively between two groups. Timepoint: To assess any difference in pH, bicarbonate and chloride levels at 12 hours by Arterial blood gas analysis and se. Creatinine at 48 hours postoperatively between two groups.

—

Countries

India

Contacts

Public ContactDr SaahithyaV

JIPMER

ashdoctor.kuberan@gmail.com9914017949

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026