Health Condition 1: R652- Severe sepsis
Conditions
Interventions
Intervention1: Intervention: Patients (1 month to 14 years old) presenting to the paediatric emergency with criteria fulfilling for septic shock will undergo a bedside ultrasonography to look for IVC
Sponsors
Dr Swasti Keshri
Eligibility
Inclusion criteria
Inclusion criteria: fulfilling the case definition of septic shock defined by survival sepsis guideline [definition of SIRS, sepsis, septic shock taken from International Paediatric Sepsis Conference, 2005.
Exclusion criteria
Exclusion criteria: 1)Hypovolemic shock â?? haemorrhagic shock, gastroenteritis, burns, trauma, diabetic ketoacidosis 2)Conditions in which volume expansion is guarded- severe anaemia eg due to sickle cell anaemia, malaria, cardiogenic shock with congestive heart failure, acute kidney injury, dengue shock 3)Severe acute malnutrition (SAM) 4)Patients who have already received some form of treatment in the form of fluid boluses or inotropes from other hospital 5)Patients who are terminally ill and will require cardiopulmonary resuscitation at presentation to Pediatric Emergency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the two groups in terms of reversal of shock in children (Group A â?? without intravenous fluid bolus and early initiation of inotropes, Group B â?? managing the shock as per survival sepsis guidelines)Timepoint: 1 hour, 6 hours, 48 hours, reversal of shock, death/discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)To compare mortality of the two groups at 48 hours and overall outcome 2)To assess for end point i.e., mean time of resolution of shock in the two groups 3)To compare volume status (preload) in the two groups- by clinical examination and by measuring IVC collapsibility by bedside ultrasound Timepoint: 1 hour, 6 hours, 48 hours, resolution of shock, length of hospital stay, final outcome(death/discharge) | — |
Countries
India
Contacts
Public ContactSwasti Keshri
AIIMS Raipur
Outcome results
None listed