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A clinical study to compare the efficacy and safety of epidural levobupivacaine and morphine as separate entities

Comparison of the Effects of Epidural Levobupivacaine And Morphine for Postoperative Analgesia following Major Abdominal Surgery â?? A Randomized Controlled Trial.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/04/033102
Enrollment
42
Registered
2021-04-26
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: levobupivacaine: Levobupivacaine, a bupivacaine S (-) isomer has a similar onset and duration of action as bu­pivacaine but with less toxic effects on the cardiovascular and central ne

Sponsors

SRM Medical College Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with ASA Physical Status I , II and III posted for major abdominal surgeries

Exclusion criteria

Exclusion criteria: Pregnancy Drug allergy Patient refusal Uncooperative patients systemic or local infection cardiac disease severe lung disease liver disease kidney disease

Design outcomes

Primary

MeasureTime frame
To compare the VAS (Visual Analogue Scale) score at rest and at coughing between levobupivacaine and morphine. Timepoint: 24 hours—

Secondary

MeasureTime frame
Haemodynamic parameters. Assessment of motor blockade. Sedation score. Need for additional analgesic such fentanyl(0.5 microgram/kg) Adverse effects such as nausea, vomiting, respiratory depression, pruritus. Timepoint: 24 hours—

Countries

India

Contacts

Public ContactRajagopalan Venkatraman

srm Medical College Hospital and Research Centre

drvenkat94@gmail.com09894581455

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 10, 2026