Health Condition 1: G560- Carpal tunnel syndrome
Conditions
Interventions
Intervention1: PREGABALIN: Capsule PREGABALIN 50 mg once daily for 1 week followed by twice daily for 1 week followed by thrice daily for another 6 weeks (total 8 weeks)
Control Intervention1: PLACEBO
Sponsors
INSTITUTE OF MEDICAL SCIENCES BHU VARANASI
La Renon Healthcare Pvt Ltd
Eligibility
Inclusion criteria
Inclusion criteria: patients with symptoms & signs of CTS(idiopathic) with at least one of the following electrophysiological features- A.Difference in Median and Ulnar sensory peak Latency >0.5ms B.Difference in Median and Ulnar motor distal latency >0.5ms C.Median sensory latency �3.6ms D.Median motor distal Latency �4.5ms
Exclusion criteria
Exclusion criteria: A.Severe CTS with thenar atrophy B.Previously operated for release of Carpal Tunnel or local steroid injection C.Secondary causes of CTS like Diabetes mellitus, rheumatoid arthritis, hypothyroidism, amyloidosis and post-traumatic D.Patients with other neurological causes like polyneuropathies, thoracic outlet syndrome, cervical radiculopathy E.Patients in whom ultrasound reveal secondary causes of carpal tunnel syndrome like Ganglion cysts, accessory muscles etc F.Not willing to participate/give consent G.Pregnant or breast feeding women H. Clinically significant cardiovascular, renal or hepatic disease I. Patients on pregabalin for other casuse like seizure disorder, trigeminal neuralgia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in BCTQ(Boston Carpal Tunnel Questionnaire) subscale score A. SSS(Symptom Severity Score) B. FSS(Functional Status Score)Timepoint: baseline,2 weeks,8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in clinical grading of CTSTimepoint: Baseline, 8 week;Change in Electro-physiological grading of CTSTimepoint: Baseline, 8 week;Change in grip strength by hydraulic hand dynamometerTimepoint: Baseline, 2 week, 8 week | — |
Countries
India
Contacts
Public ContactDR KUMAR BISMAYA
INSTITUTE IF MEDICAL SCIENCE,BHU
Outcome results
None listed