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Use of an â??Oral Tabletâ?? to improve chances of Vaginal Delivery by softening the opening of the Womb( Cervix)

Randomized control trial to estimate the effect of Mifepristone in pre induction ripening of cervix in term pregnancy.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/04/033044
Enrollment
232
Registered
2021-04-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Tab Mifepristone 400 mg: Tab Mifepristone 400 mg Orally Single dose to term pregnant woman and observe Bishops score at 24 and 48hrs Control Intervention1: No Treatment: No Treatment

Sponsors

Dr Yogindrakumar M Kabadi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: INCLUSION CRITERIA: 1.Singleton Pregnancy 2.Term gestation (37-42weeks) 3.Cephalic presentation 4.Intact membranes 5.Reactive fetal heart rate pattern in CTG 6.Consenting to participate in the study 7.Adequate pelvis 8.Unfavourable cervix with Modified Bishop score

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA: 1.Hypersensitivity to Mifepristone. 2.Cardiovascular, Renal, Hepatic disease, Asthma. 3.Cases of severe Pregnancy Induced Hypertension. 4.Any contraindication for vaginal delivery or Mifepristone. 5. Abruption

Design outcomes

Primary

MeasureTime frame
changes in modified bishops scoreTimepoint: at 24 and 48 hours or whenever she comes with labor pain—

Secondary

MeasureTime frame
APGAR score and need for NICU admissionTimepoint: at birth of the newborn;maternal third stage complicationsTimepoint: at delivery and upto two hours after delivery;need for inductionTimepoint: at 48 hrs;ripening to delivery intervalTimepoint: at delivery—

Countries

India

Contacts

Public ContactDivyashree Bhat

karnataka institute of medical sciences hubli

omkabadi@gmail.com9448210579

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026