Health Condition 1: L80- Vitiligo
Conditions
Interventions
Intervention1: Narrow band ultraviolet B: An initial dose of 200 mJ/cm2 will be administered and increased by 20% at each visit up to a maximum of 1400 mJ/cm2 subject to each patient’s tolerance
Contr
Sponsors
Vinay K
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients of non-segmental vitiligo involving 10-50% of body surface area 2. Age 12-60 years 3. Unstable disease, defined as occurrence of new lesion(s), progression of existing lesion(s) or Koebnerization.
Exclusion criteria
Exclusion criteria: 1. Patients of segmental vitiligo and universal vitiligo 2. Any systemic treatment in the past 12 weeks 3. Contraindication to use of NBUVB phototherapy including xeroderma pigmentosa, systemic lupus erythematosus and other photo-induced or photo-aggravated dermatoses 4. Intake of phototoxic drugs 5. History of skin malignancy, premalignant skin lesions and dysplastic naevi 6. Claustrophobia 7. Hepatic and renal dysfunction 8. Immunosuppression 9. Associated connective tissue diseases including but not limited to systemic lupus erythematosus, rheumatoid arthritis 10. Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of pre and post treatment skin biopsies by H and E, CD8+ T cell count, CD8+ CD45+ memory T cells, CD8+, CD69+ CD103+ TRM cells and FOXP3+ Treg cells and for growth factors endothelin 1, SCF, bFGF, alpha MSH Assessment of pre and post treatment blister fluid analysis for chemokines like CXCR3, CXCL9, CXCL10, IFN-?, IL1ßTimepoint: 48 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical examination, Wood’s lamp examination and dermatoscopic evaluation of lesional skin; assessment of disease severity and activity by VASI and VIDA and whole body clinical photographyTimepoint: 4 weeks, 8 weeks, 12 weeks, 16 weeks, 20 weeks, 24 weeks, 28 weeks, 32 weeks, 36 weeks, 40 weeks, 44 weeks, 48 weeks | — |
Countries
India
Contacts
Public ContactVinay K
Post Graduate Institute Of Medical Education And Research
Outcome results
None listed