Comparing two drugs in two different routes for reducing the cardiovascular changes associated with laryngoscopy and intubation.

â??Attenuation of hemodynamic response to laryngoscopy and endotracheal intubation : A comparison between intranasal dexmedetomidine and intravenous preservative free lignocaine - A one year hospital based double blinded randomised clinical trial.â??

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/04/032996

Enrollment

Registered

2021-04-22

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K352- Acute appendicitis with generalized peritonitis Health Condition 2: O- Medical and Surgical

Interventions

Control Intervention1: Inj.DEXMEDETOMIDINE vs Inj. PRESERVATIVE FREE LIGNOCAINE: Inj.DEXMEDETOMIDINE 1mcg/kg is administered 30 MINS BEFORE INTUBATION INTRANASALLY and Inj. PRESERVATIVE FREE LIGNOCAIN

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA 1 and 2 2.Patients undergoing elective surgeries under general anaesthesia with endotracheal intubation. 3. Provides consent

Exclusion criteria

Exclusion criteria: 1. Patient refusal or who are unable to give consent. 2. ASA physical status 3 or more. 3. Patients allergic to drug under study. 4. Patients undergoing emergency surgery. 5. Patients with nasal pathology.

Design outcomes

Primary

Measure	Time frame
Comparision of intranasal dexmedetomidine with intravenous preservative free lignocaine with respect to hemodynamic variables like Mean arterial pressure, Systolic blood pressure, Diastolic blood pressure and Heart rate.Timepoint: Pre induction for Dexmedetomidine 0mins 10 mins 20 mins 30 mins Pre induction for Lignocaine 0min 3mins Post induction for both dexmedetomidine and lignocaine atL-I 1min 2min 3min 4min 5min 7min 10min	—

Measure

Time frame

Comparision of intranasal dexmedetomidine with intravenous preservative free lignocaine with respect to hemodynamic variables like Mean arterial pressure, Systolic blood pressure, Diastolic blood pressure and Heart rate.Timepoint: Pre induction for Dexmedetomidine 0mins 10 mins 20 mins 30 mins Pre induction for Lignocaine 0min 3mins Post induction for both dexmedetomidine and lignocaine atL-I 1min 2min 3min 4min 5min 7min 10min

—

Secondary

Measure	Time frame
To determine the incidence of side effects and complications.Timepoint: 0 to 10 mins	—

Countries

India

Contacts

Public ContactSushmitha HS

Dr Prabhakar Kore Hospital , JNMC

vandanagogate@gmail.com9844083030

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026