Health Condition 1: K807- Calculus of gallbladder and bile duct without cholecystitis Health Condition 2: K409- Unilateral inguinal hernia, without obstruction or gangrene
Conditions
Interventions
Intervention1: Intravenous Dexmedetomidine: In Group-D dexmedetomidine loading infusion (1µg/kg) will be administered over 10 min followed by continuous IV infusion at 0.5 mcg/kg/h.
Control Intervent
Sponsors
Shri Ram Murti Smarak Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: A total of 93 patients aged 18-60 yrs. of either sex with ASA physical status I/II undergoing elective laparoscopic surgeries will be enrolled in the study.
Exclusion criteria
Exclusion criteria: patient refusal, hypersensitivity to the drugs being evaluated, Body Mass Index (BMI) more than 40 kg/m2, pregnancy, significant comorbid conditions like uncontrolled hypertension, congestive heart failure, myocardial infarction in the past 6 months, heart block, fixed cardiac output lesions, chronic liver or kidney illnesses and chronic use of opioids/opioid addiction, steroids, or inability to comprehend postoperatively the pain assessment scale/neuropsychiatric disorders, patients requiring inotropes or antihypertensive medications intraoperatively.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure of our study is to compare the analgesic effects of intraoperative lidocaine and dexmedetomidine infusion on intraoperative and immediate postoperative opioid consumption in patients undergoing laparoscopic surgeries and assessing the VAS at predetermined points i.e., immediately after tracheal extubation, 15 min, 30 min and then hourly until the first rescue analgesic. Mean and cumulative VAS scores and sedation scores shall be compared between the three groups.Timepoint: immediately after tracheal extubation, 15 min, 30 min and hourly until the first rescue analgesic | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome measures include analysing intraoperative hemodynamic profile (heart rate and mean arterial pressure) and incidence of adverse effects including intraoperative and postoperative hemodynamic changes, post-operative constipation, sedation, pruritus, PONV and analyzing recovery profile (by comparing RASS at predetermined end pointsTimepoint: At baseline(0), induction, tracheal-intubation, before pneumoperitoneum, 15-minute intervals, end-surgery in both groups, immediately after tracheal extubation, 15 min ,30 min, and hourly till RASS score zero. | — |
Countries
India
Contacts
Public ContactDr Ashita Mowar
Outcome results
None listed