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To determine the effectiveness of platelet rich plasma in alteration of disease progression in early rheumatoid arthritis

Comparison of conventional disease modifying anti-rheumatic drugs with and without Intra-articular platelet rich plasma injection in the alteration of disease progression of early rheumatoid arthritis: A randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/04/032935
Enrollment
50
Registered
2021-04-19
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M057- Rheumatoid arthritis with rheumatoid factor without organ or systems involvement

Interventions

Intervention1: Intra-articular platelet rich plasma(PRP) injection along with Triple combination DMARDs therapy: Two ml of platelet rich plasma injection in wrist joint under ultrasound guidance in ad

Sponsors

Regional Institue of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient fulfilling 2015 American College of Rheumatology criteria for adult early RA 2. Grey scale ultrasound finding of joint effusion and synovial hypertrophy without bone erosion 3. Age group : 18-50 years

Exclusion criteria

Exclusion criteria: 1. Patient with wrist deformity 2. Thrombocytopenia (less than 1.8 lakhs /cumm) 3. Hypofibrinogenemia 4. Anticoagulation medications 5. Acute and chronic infections 6. Tubercular arthritis of wrist joint 7. Chronic liver disease 8. Patient who received corticosteroid injection in the last 6 weeks 9. Pregnancy

Design outcomes

Primary

MeasureTime frame
1. Pain measured by using Visual analogue scale (VAS) 2. Disease activity using Disease activity score 28 (DAS 28-ESR) Timepoint: At the end of 8 weeks and 20 weeks—

Secondary

MeasureTime frame
1.Disease activity using Disease activity score 28 (DAS 28-ESR) 2.. Hand function by using The Cochin Rheumatoid hand functional scaleTimepoint: At the end of 8 weeks and 20 weeks—

Countries

India

Contacts

Public ContactAkoijam Joy Singh

REGIONAL INSTITUTE OF MEDICAL SCIENCES

joyakoijam2@yahoo.com9436026960

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026