Health Condition 1: D000- Carcinoma in situ of lip, oral cavity and pharynx Health Condition 2: K135- Oral submucous fibrosis
Conditions
Interventions
Intervention1: 1. incisional biopsy
2. intralesional injection: Patients clinically diagnosed as grade 2 and grade 3 Oral submucous fibrosis visiting Department of Oral and Maxillofacial surgery and D
Sponsors
Govt Dental College
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients clinically diagnosed as Grade 2 and Grade 3 Oral submucous fibrosis. 2. Individuals with no underlying systemic disease 3. Individuals ready for the study procedure and who will give written consent to undergo the study willingly .
Exclusion criteria
Exclusion criteria: 1. Patients suffering from systemic conditions such as diabetes, hypertension, bleeding disorders, thyroid disorders 2. Patients allergic to steroids. 3. Patients with trismus but no palpable fibrous bands. 4. Patients unwilling to undergo the study and do not give informed written consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To measure the improvement in clinical mouth opening after intralesional steroidal treatment 2. To check the efficacy of Triamcinolone acetamide with Hyaluronic acid in treatment of oral submucous fibrosis.Timepoint: 9 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To investigate the types collagen fibers among different grades of oral submucous fibrosis 2. To compare the difference in pattern of distribution, types and color profile of collagen fibers before and after giving intralesional steroids in oral submucous fibrosis. 3. To compare the effectiveness of picrosirius red stain under polarizing microscopy with routine microscopy for evaluation of the collagen parameters such as types, orientation and color profile.Timepoint: 9 months | — |
Countries
India
Contacts
Public ContactDr Varthangpuii
GOVERNMENT DENTAL COLLEGE AND HOSPITAL, MUMBAI
Outcome results
None listed