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TO QUANTIFY AND COMPARE THE LEVELS OF miRNA 155 IN HEALTHY AND DISEASED GINGIVAL TISSUES AND ITS EFFECT ON BONE RESORBING CELLS.

COMPARATIVE EVALUATION OF microRNA-155 EXPRESSION AND ITS EFFECT ON OSTEOCLAST DIFFERENTIATION, MEDIATED BY MICROPTHALMIA INDUCED TRANSCRIPTION FACTOR (MITF) IN HEALTHY AND PERIODONTITIS AFFECTED GINGIVAL TISSUES.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2021/04/032800
Enrollment
98
Registered
2021-04-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

None listed

Sponsors

N SOWMYA REDDY
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: INCLUSION CRITERIA FOR PERIODONTALLY DISEASES GINGIVAL TISSUES 1)Patients with age group >= 18years 2)Patients with Stage III Periodontitis and Stage IV Periodontitis (according to 2017 EPF/AAP Classification) 3)Gingival Index >= 1 4)Periodontal Probing depth >= 6mm 5)Clinical Attachment Loss >= 3mm 6)Radiographic evidence of bone loss >= 50% EXCLUSION CRITERIA 1)Diabetic Patients 2)Patients with any other systemic diseases/ auto immune diseases 3)Patients under medication with immuno suppressants, antibiotics, anti-inflammatory drugs in the last six months 4)Pregnant or lactating mothers. 5)Smokers ( current and past) 6)Previous history of periodontal therapy

Exclusion criteria

Exclusion criteria: 1)Diabetic patients 2)Patients with any other systemic diseases/ auto immune diseases 3)Patients under medication with immuno suppressants, antibiotics, anti inflammatory drugs in the last 6months, 4)Pregnant or lactating mothers, 5)smokers 6) previous history of periodontal therapy

Design outcomes

Primary

MeasureTime frame
1)quantify and compare the expression of miRNA 155 in periodontal disease and healthy gingival tissues 2)To quantify and compare the expression of Micropthalmia Induced Transcription Factor (MITF) in periodontal disease and healthy gingival tissues Timepoint: at baseline—

Secondary

MeasureTime frame
1. To compare and correlate the miR-155 levels and Micropthalmia Induced Transcription Factor levels in periodontal disease and healthy gingival tissues 2. To compare and correlate the miR-155 levels and Micropthalmia Induced Transcription Factor levels in periodontal disease and healthy gingival tissues with the clinical parameters Timepoint: at baseline—

Countries

India

Contacts

Public ContactDEVA PRIYA APPUKUTTAN

SRM DENTAL COLLEGE

devapriyamds@gmail.com09840197121

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026