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Effect of two drugs (Dexmedetomidine versus fentanyl) on surgical stress in laparoscopic cholecystectomy in non-diabetic patients.

Comparison of effect of dexmedetomidine versus fentanyl to assess neuroendocrine stress response in laparoscopic cholecystectomy in non-diabetic patients.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/04/032780
Enrollment
60
Registered
2021-04-13
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Fentanyl: Patients will be premedicated with either of the two drugs over a ten minute period before induction of anaesthesia. Group F will be given intravenous fentanyl 2 microgram per

Sponsors

Dr Rajni Gupta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients giving informed written consent ASA grade 1 Patients undergoing laparoscopic cholecystectomy under general anaesthesia

Exclusion criteria

Exclusion criteria: ASA grade 2,3 and 4 Age less than 18 years or more than 70 years. Presence of cholecystitis at the time of surgery Choledocholithiasis Need for conversion to open cholecystectomy Patients with abnormal blood urea nitrogen Patients not giving written informed consent.

Design outcomes

Primary

MeasureTime frame
To compare the effects of dexmedetomidine and fentanyl premedication on neuroendocrine stress response attenuation perioperatively.Timepoint: One year

Secondary

MeasureTime frame
To analyse the effects of dexmedetomidine and fentanyl on blood glucose and serum cortisol levels perioperatively. To evaluate the effects of dexmedetomidine and fentanyl on haemodynamic parameters and their stability during laparoscopic cholecystectomy.Timepoint: One year

Countries

India

Contacts

Public ContactDr Rajni Gupta

King George Medical University

rgkgmu@gmail.com9839288980

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026