Study of using patients own tissues to construct mitral valve compared to mechanical valve replacement

Autopericardial Mitral valve re-implantation versus Mitral valve replacement with prosthetic valve: A comparative study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/04/032759

Enrollment

100

Registered

2021-04-12

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: I052- Rheumatic mitral stenosis with insufficiency

Interventions

Intervention1: MV Auto: Autopericardial Mitral valve reconstruction Control Intervention1: MVR: Mitral valve replacement

Eligibility

Inclusion criteria

Inclusion criteria: Patients with mitral valve diseases including stenosis, regurgitation, prolapse and infective endocarditis, not amenable for mitral repair.

Exclusion criteria

Exclusion criteria: Severe LV dysfunction, multiorgan failure

Design outcomes

Primary

Measure	Time frame
Survival Disease free survival Symptom free survival Freedom from re-intervention Timepoint: At discharge , 4 weeks 6 months 1 year 5 years	—

Secondary

Measure	Time frame
Post-operative Mitral Valve Orifice Area (MVOA) Post-operative mitral valve residual gradient Left ventricular regression post surgery Timepoint: 1 month 3 moth 6 months 1 year 5 years	—

Countries

India

Contacts

Public ContactPrabhu Manohar

Sri Jayadeva Institute of Cardiovascular Sciences and Research

dr.prabhu.manohar.03@gmail.com9483964910

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026