Health Condition 1: K701- Alcoholic hepatitis
Conditions
Interventions
Intervention1: Prednisolone: oral route,Dose 40mg, twice a day for 28 days.
Control Intervention1: Nill: Nill
Sponsors
SRM Medical College Hospital and Research Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Presentation with clinically diagnosed alcoholic hepatitis. 2. Maddreyâ??s discriminate function >32 (Used in corticosteroid therapy & identifying the Risk factors) 3. Lille score >0.45 ( Identification of responding to corticosteroid therapy after 1 week) 4. MELD Score ( Model of end stage live disease) >18 indicates SAH
Exclusion criteria
Exclusion criteria: Multi-organ Dysfunction,Uncontrolled infection,Patients with a serum creatine >500µmol/L or requiring renal support,Hepatocellular carcinoma,Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine the overall response rate (complete response +partial response) to Pharmacogenetic based prednisolone therapy in patients with previously untreated alcoholic hepatitis.Timepoint: first response rate can be measured at 1st week from the day of the therapy for 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To access the ADR in Alcoholic Hepatitis PatientsTimepoint: from 1st week to 4 th week measurment of ADRs were monitored. | — |
Countries
India
Contacts
Public ContactDr T M Vijayakumar
SRM Medical College Hospital and Research Center
Outcome results
None listed