Health Condition 1: L501- Idiopathic urticaria
Conditions
Interventions
None listed
Sponsors
Department of dermatology venereology and leprology
Eligibility
Inclusion criteria
Inclusion criteria: Patient is called to have chronic spontaneous urticaria when there is â??Spontaneous appearance of wheals, angioedema or both for > 6 weeks due to known (For example, autoreactivity, that is the presence of mast cell-activating auto-antibodies) or unknown causesâ?? 1 Inclusion criteria 1. Patients fulfilling above definition. 2. Age >= 18 years.
Exclusion criteria
Exclusion criteria: 1. Acute urticaria ( 2. H/o syncopal attack and bronchospasm during preceding episodes of urticaria which is indicative of anaphylaxis. 3. Age 4. Chronic inducible urticaria 5. Urticarial vasculitits. 6. Patients suffering from hereditary angioedema (HAE).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Primary objective To correlate the levels of serological markers (IL-9, C5a, Apolipoprotein A-IV) with disease severity using UAS-7 and to assess the difference in levels of these markers between the patients responding to antihistamines to those who are not responding to antihistamines. Timepoint: Baseline, 15th day, 30th day, 60th day, 90th day | — |
Secondary
| Measure | Time frame |
|---|---|
| 2. Secondary objective a). To correlate the levels of serological markers(IL-9, C5a, Apolipoprotein A-IV) with total serum IgE, Thyroid profile with anti TPO antibodies in patients with chronic spontaneous urticaria Timepoint: Baseline, 15days, 60days, 90 days | — |
Countries
India
Contacts
Public ContactDr M Sendhil Kumaran
PGIMER, Chandigarh
Outcome results
None listed