A clinical trial to study the effects of photodynamic therapy in the management of gum disease

Comparing the efficacy of photodynamic therapy with 1% malachite green or 1% methylene blue when used adjunctively to scaling and root planing in the treatment of chronic periodontitis

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2021/04/032704

Enrollment

Registered

2021-04-09

Start date

Unknown

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: 1% malachite green : 1% malachite green at baseline. Control Intervention1: 1% methylene blue: 1% methylene blue at baseline.

Eligibility

Inclusion criteria

Inclusion criteria: A minimum of one tooth each in two contralateral quadrants having at least one site with a probing depth of = 5mm and = 7mm. Systemically healthy patients. Not received any antibiotics in the past 6 months. Plaque and Gingival index score of less than 1

Exclusion criteria

Exclusion criteria: Smokers. Pregnant and lactating women. Allergic to malachite green or methylene blue. Active periodontal treatment within the last 6 months.

Design outcomes

Primary

Measure	Time frame
Changes in probing depth(PD) and clinical attachment level(CAL) will be observed in the experimental sites.Timepoint: baseline, 3 months, 6 months	—

Secondary

Measure	Time frame
Changes in plaque index scores, gingival index scores and bleeding index scores will be documentedTimepoint: At the baseline visit, 3 months and 6 months	—

Countries

India

Contacts

Public ContactVinaya Kumar R

Rajarajeswari Dental College and Hospital

drrvinayakumar@gmail.com9844301016

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026