Effect of using sweetener sucralose for 12 weeks on body weight, glycemic and lipid parameters among adults with diabetes in India

Conditions

None listed

Haslam DE, Abirami K, Starr JR, Unnikrishnan R, Lasky-Su J, Gayathri R, Gokulakrishnan K, Manasa VS, Rimm EB, Anjana RM, Krishnaswamy K, Hu FB, Sudha V, Mohan V, Bhupathiraju SN.

2025-11-12

10.1016/j.cdnut.2025.107600

Effect of Replacing Sucrose in Beverages with Nonnutritive Sweetener Sucralose on Cardiometabolic Risk Factors Among Asian Indian Adults with Type 2 Diabetes: A 12-Week Randomized Controlled Trial.

Mohan V, Manasa VS, Abirami K, Unnikrishnan R, Gayathri R, Geetha G, RamyaBai M, Padmavathi S, Rajalakshmi M, Pradeepa R, Anjana RM, Krishnaswamy K, Sudha V.

2024-07-246 citations

10.1007/s13300-024-01622-6

46-LB: Effect of Nonnutritive Sweetener (Sucralose) on Gut Microbiome in Asian Indian adults with Type 2 Diabetes—A Randomized Clinical Trial

Viswanathan Mohan, Kuzhanthaivelu Abirami, Rajagopal Gayathri, P. Soundararajan, Ranjit Unnikrishnan et al. (8 authors)

Diabetes2023-06-201 citations

10.2337/db23-46-lb

Interventions

Intervention1: LCS- sucralose (pellet/powder/liquid form): Participants will be advised to use LCS-Sucralose (in either pellet or powder or liquid form) in place of sugars in tea/coffee/ beverages for

Eligibility

Inclusion criteria

Inclusion criteria: .Adults with type 2 diabetes and BMI greater than 18.5 .Hba1c 8-12% .Individuals on stable OHA/insulin dose .Willing to follow study protocol .Willing to give informed consent .Willing to use LCS-sucralose for 12 weeks

Exclusion criteria

Exclusion criteria: .Any acute infections like viral fever, typhoid, cold, diarrhea, constipation last 1 month .Individuals with any disorders of liver, kidney, thyroid, or other endocrine diseases or other complications such as respiratory disorders, diabetes, cancer or heart attack and stroke that hinders the intervention .Individuals with any eating disorder .Participants undergoing any treatment or medications including antibiotics .Pregnant and lactating Women .Plans to relocate in the next 3 years. .Planning longer duration of travel out of town

Design outcomes

Primary

Measure	Time frame
Assessing the change in HbA1c with LCS- sucralose (pellet/powder/liquid form)Timepoint: 12 weeks	—

Secondary

Measure	Time frame
Assessing the effect of LCS-sucralose on body weight Glycemic parameters ,Lipid profile,Inflammatory markers, Advanced glycation end products and Gut microbiome Timepoint: 12 weeks	—

Countries

India

Contacts

Public ContactMrs Sudha Vasudevan

Madras Diabetes Research Foundation

s2r_7@mdrf.in04443968487

Outcome results