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Comparison of the effect of two drugs Lansoprazole and Dexlansoprazole on stomach contents and its volume before operation in patients scheduled for surgery.

Effect of oral Lansoprazole versus Dexlansoprazole as premedicant on gastric residual volume in patients receiving general anaesthesia for elective surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/04/032601
Enrollment
150
Registered
2021-04-07
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Lansoprazole: Tablet 30 mg on the night before surgery and on the day of surgery with sips of water Intervention2: Dexlansoprazole: Tablet 30 mg on the night before surgery and on the d

Sponsors

GMCH Chandigarh Department of Anaesthesia and Intensive Care
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. American Society of Anaesthesiologists (ASA) physical status I or II. 2. Age group 18-80 years of either sex. 3. Patients scheduled to undergo elective surgery under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1. Patients with history of prior gastric or lower esophageal surgery. 2. Patients with known abnormalities of the upper gastrointestinal tract (such as hiatal hernias and gastric tumors). 3. Pregnancy. 4. Patients unable to turn and lie in lateral position. 5. Patients with BMI more than 35kg/m2. 6. Patients with known acid peptic disease, gastric or duodenal diseases. 7. Failure of passing NG tube or obtain gastric aspirate. 8. Patients who are allergic to proton pump inhibitors. 9. Patients who are not able to understand the study procedure and provide informed written consent.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the efficacy of lansoprazole and dexlansoprazole in reducing preoperative gastric residual volume in patients scheduled to undergo elective surgery under general anaesthesiaTimepoint: After 8 hours of fasting—

Secondary

MeasureTime frame
1. To compare the efficacy of lansoprazole and dexlansoprazole in increasing the fasting gastic pH by the use of a digital pH meter in patients undergoing elective surgery under general anaesthesia. 2. To find correlation between the measured gastric residual volume and gastric pH with any underlying co-morbidities. 3. To evaluate and assess any possible side effects, if any, of the above mentioned proton pump inhibitors.Timepoint: After 8 hours of fasting—

Countries

India

Contacts

Public ContactDr Sanjeev Palta

Government Medical College and Hospital, Chandigarh

richajayant@rediffmail.com9646121513

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026