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Comparing response of Aprepitant and Ondansetron with only Aprepitant in Post operative nausea and vomiting in craniotomy patients.

Comparison of Aprepitant and Ondansetron versus Aprepitant alone for prevention of post operative Nausea and Vomiting in patients undergoing elective craniotomy.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2021/04/032588
Enrollment
168
Registered
2021-04-06
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: ANTI EMETIC AGENTS: APREPITANT AND ONDANSETRON VERSUS APREPITANT ALONE Intervention2: POST OPERATIVE NAUSEA AND VOMITING: NIL Control Intervention1: Aprepitant and ondansetron: Tab Apre

Sponsors

DEPARTMENT OF ANAESTHESIOLOGY AND CRITICAL CARE JNMC ALIGARH MUSLIM UNIVERSITY
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists(ASA) physical status I & II patients of either sex scheduled to undergo elective craniotomy under General Anaesthesia.

Exclusion criteria

Exclusion criteria: (1) Patients with a history of motion sickness or gastrointestinal disease. (2) Patients receiving antiemetics within 24 hours before surgery, (except Dexamethasone). (3) Patients with cardiovascular disease like coronary artery disease, hypertension, etc. (4) Pulmonary disease like asthma, COPD, cor-pulmonale. (5) Patients with neuro-muscular, hepatic or major renal disease. (6) History of alcohol, drug abuse or smokers. (7) History suggestive of hiatus hernia/GERD. (8) GCS less than 13.Â

Design outcomes

Primary

MeasureTime frame
To measure the incidence of Post-Operative Nausea and Vomiting during first 24 hours after surgery.Timepoint: 24 hours after surgery—

Secondary

MeasureTime frame
1.Severity of nausea and vomiting. 2.Number of emetic episodes. 3.Incidence of complete response. 4.Patient Satisfaction Score. 5.Timing of first dose of rescue anti emetic. 6.Time to first emetic episode. 7.Timing of first dose of rescue analgesic. 8.Incidence of side effects. Timepoint: 24 hours—

Countries

India

Contacts

Public ContactObaid Ahmed Siddiqui

Jawaharlal Nehru Medical College

obaidahmad2008@gmail.com9897695761

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026