Health Condition 1: C19- Malignant neoplasm of rectosigmoidjunction
Conditions
Interventions
Intervention1: Restrictive (â??zero balanceâ??) intravenous fluid therapy: The restrictive group fluid regimen was designed to provide 2.0 L water and 120 mmol sodium per day. Induction of anaesthesia
no other intravenous fluids will be used at the initiation of surgery (unless indicated by goal-directed device). Hartmanns solution or comparable balanced salt crystalloid at 5 mL/kg/hour will be adm
then a postoperative infusion rate of 0.8 mL/kg/hour until cessation of intravenous fluid therapy within 24 hours. The rate of postoperative fluid replacement can be reduced if there will be evidence
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: We will include the following patients: Adults (>=18 years) of either sex undergoing elective major Abdominal & Gynaecological surgeries. All these patients have increased risk of postoperative complications, defined by at least one of the following criteria: age >=70 years known or documented history of coronary artery disease known or documented history of heart failure diabetes currently treated with an oral hypoglycemic agent and/or insulin preoperative serum creatinine >200 μmol/L ( >2.8 mg/dL) morbid obesity (body mass index [BMI] >=35 kg/m2) preoperative serum albumin anaerobic threshold (if performed) or two or more of the following risk factors: â??â??American Society of Anesthesiologists (ASA) physical status 3 or 4 â??â??chronic respiratory disease â??â??obesity (BMI 30â??35 kg/m2) â??â??aortic or peripheral vascular disease â??â??preoperative hemoglobin â??â??preoperative serum creatinine 150â??199 μmol/L ( >1.7 mg/dL) â??â??anaerobic threshold (if performed) 12â??14 mL/kg/min.
Exclusion criteria
Exclusion criteria: We will apply the following exclusion criteria: Urgent or time-critical surgery ASA physical status 5 Chronic renal failure requiring dialysis Liver resection Minor or intermediate surgery,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change serum creatinine and cystatin -CTimepoint: in 72 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Delta change in serum sodium, potassium and chloride levelsTimepoint: with in 48 hours | — |
Countries
India
Contacts
Public ContactAjit Kumar
AIIMS RISHIKESH
Outcome results
None listed